Tuberculosis, due to its relentless nature, is now a major public health threat. The concomitant resurgence of TB with the MDR- or XDR-TB and HIV/AIDS pandemic has exposed the frailties of the current drug armatorium. Based on good structural similarity between BM-212, a novel antimycobacterial agent undergoing clinical trials, and 1,4,5 trisubstituted Pyrrole-3-Carbonitrile, we have designed novel 2-Amino-4,5-Diphenyl-1-(Substituted)-1H-Pyrrole-3-Carbonitrile All the compounds were screened for their antimycobacterial activity on mycobacterium tuberculosis using H37Rv strain by 1% proportion method. Some of the synthesized compounds exhibited potent antimycobacterial activity with MIC values in the range of 12.5-100 µg/mL. Key words: Anti-tubercular, Pyrrole-3-Carbonitrile