Drug delivery through oral route is widely accepted through all over world. Mouth dissolving tablet is most suitable tablet than conventional tablet. The main characteristic which is in the favors of mouth dissolving tablet is that there is no need of water to take it. Due to this it become more suitable dosage form for pediatric and geriatric patients. Since bioavailability of mouth dissolving tablet is high than conventional tablet, and mixing of piperine with it make them much more advance dosage form. Due to the addition of piperine in the drug, the dose size is reduced, and enhanced the onset of action. Addition of piperine with norfloxacin also increase the antibacterial activity and make them more effective.