In India. Fixed Dose Combinations(FDCs) have drawn the attention of health service providers and the service recipients. Therefore, the development of fixed dose combinations (FDCs) is becoming increasingly important from a public health  perspective. The objective was to study the prescribing pattern and to assess the rationality of fixed dose combinations using seven point criteria. During the study period a total of 100 patients were enrolled based on inclusion and exclusion criteria. The study population includes an overall 56% male with an average age of 46.15 ± 19.33 years. A total of 538 drugs were prescribed to the patient with a mean of 5.38±5.77.The major therapeutic category of drugs prescribed were antibiotics (30.03%), antihypertensives (12.63%) and others (13.01%).The study population had 130 FDCs in which again antibiotics topped the list, followed by Anti-diabetics. Among these 92 contributed to antibiotic FDCs belonging to 15 different groups. The average interaction per prescription was 1.96±3.72.The FDCs involved in drug interaction were aspirin+clopidogrel, amoxicillin+ clavulanic acid. The average length of stay for study population was found to be 5.73±2.19 days. The rationality was assessed using 7 point criteria with a maximum scoring of 14. The most commonly prescribed combination were Piperacillin + Tazobactam (25.38%) and Amoxicillin+ Clavulanic acid(16.92%).Among the combinations, 26.6% scored 13 while 66.66% scored 9-12 and 6.66%scored 7. The results indicated that majority of FDCs especially antibiotics were rational.