The anti-ulcer activity of leaves of benzene and pet ether extract of cleome gynandra inn was investigated in  ethanol induced ulcer model in the male wistar albino rats. The parameters evaluated are ulcer index ,volume of gastric juice, gastric acidity, ph of gastric juice. Pet ether and benzene extract  at doses of 150 mg/kg produced significant inhibition of gastric lesion induced by ethanol induced gastric ulcer. The extract shows significant reduction in gastric volume ,and ulcer index when compared to control. The present study indicates that leaves of benzene and pet ether extract of cleome gynandra inn have potential anti ulcer activity in ethanol induced ulcer model. Further the study also implies that dietary polyphenolic phytochemical especially the flavonoid, saponins accumulated in leaves may supply substantial anti-ulcer agents, which in turn may inhibit the development of several chronic  diseases and there by provide health promoting effect.