The methanolic extract of Punica granatum (PUG), Glycyrrhiza glabra (GLA) and their combination (PUG-GLA) were evaluated for their wound healing activity using excision wound model in rats. Rats treated with PUG-GLA showed higher rate of wound contraction, significant decrease in epithelization period and significant increase in hydroxyproline content of granulation tissue when compared with the controls. The histological examination of treated wounds showed that the original tissue regeneration was much greater in PUG-GLA, with increase in the restoration of collagen fibers, fibroblasts, blood vessel formation and hair follicle regeneration.