To synthesize and characterize novel thiazolidinone derivatives and screen them for anti tubercular activity. A series of ten 2-(substituted phenyl)-3-[{4-(1-naphthyl)-1, 3-thiazol-2-yl} amino]-5-methyl-1, 3-thiazolidin-4-ones (TM1-TM10) were synthesized from 1-acetyl naphthalene. The synthesized compound, characterized on the basis of satisfactory analytical and spectral (IR, H1NMR, Mass and elemental) data. Studies were carried out for the synthesized compounds which were also evaluated for anti-tubercular activity by using Lowenstein-Jensen (LJ) acid medium and screening by Cup plate method. Rifampicin (Lupin) is used as standard antitubercular agents. The synthesized compounds showed good anti tubercular activity, compared to standard drugs. Two of the compounds TM1 (Ar = 4-nitrophenyl) and TM6 (Ar = 3-fluorophenyl) exhibited significant anti-tubercular activity, as compared to standard drug Rifampicin. We report the successful synthesis of novel thiazolidinones, as well as their spectral characterization, and anti tubercular activity which, for some, is superior to currently used anti-tubercular agents.