Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by fibrosis and vasculopathy. It is a rapidly progressing disease and wide spreading dysfunctioning of various organs includes kidney, gastro intestinal, cardiovascular systems and etc. Annual incidence is 19 per million, and prevalence is 19-75 per 100,000, with a female: male ratio of 3:1, and 8:1 in mid to late childbearing years. Incidence is twice as high among African Americans. The data was collected from in-patient record book in the Deportment of Dermatology in a tertiary care hospital in India for a period of March 2011 to February 2013. A total of 180 patients were recorded in the in-patient record book of the Department of Dermatology in a tertiary care hospital for a period of March 2011to February 2013. Among the patients of systemic Sclerosis the dominating age groups were 21 to 30 years and 31to40 years. In the study most of the females 144 (80%) patients out of 180, males 36 (20%) patients out of 180 are having Systemic sclerosis disease. The female/male ratio of disease is 4:1.