The present work objective are to investigate the wound healing activity of some indigenous plant’s (Ipomoea Carnea  and N.Oleander Linn) leave extracts in Wister Albino Rats using two different models Viz., excision and incision model. In the form of an ointment with two concentrations (5% and 10% w/v ointment of methanolic leave extract in simple ointment base). Higher concentration of both concentrations of the methanolic extracts showed significant response in both the wound types tested when compared with the control group. From both the plants 10 % w/v ointment of plant Ipomoea carnea leave extracts on topically showed more significant activity than other test compounds. Nitrofurazone ointment (0.2%w/w) used as standard. Keywords- Methanol extract, I. Carnea, N. Oleander Linn, Excision, Incision, Nitrofurazone.