Microsphere is a carrier system for delivery of therapeutic candidate. Nasal microspheres offers significant advantages over other type of drug delivery system. It modulates absorption characteristics of the drug by enhancing drug residence time in the nasal cavity and subsequently may increase bioavailability profile of administered drug. Prior to formulation some physicochemical properties of drug are need to be considered like molecular weight, solubility, pKa and partition coefficient of drug etc. Till date various methods have been adopted for fabrication of nasal microspheres are like spray drying, emulsion crosslinking, Solvent Evaporation etc. Obtained microspheres can characterized for various properties like its morphology, drug content, and zeta potential etc. Present  review mainly focuses on overview of microsphere technology for nasal administration of drug.