Several five membered aromatic systems having three heteroatoms at symmetrical positions such as thiadiazoles have been studied extensively owing to their interesting pharmacological activities.  Compounds containing thiadiazole moiety possess interesting biological activity due to strong aromaticity of this ring system that leads to great in vivo stability and lack toxicity. Thiadiazoles are an important class of heterocyclic compounds that exhibit diverse applications in organic synthesis, pharmaceutical and biological applications that exhibits a wide variety of biological activities like antimicrobial, anti-inflammatory activity, antitubercular activity, antidiabetic activity, diuretics, antidepressant & cytotoxic activity. Modification of the thiadiazole ring has proven highly effective with improved potency and lesser toxicity. The present review highlights the recently synthesized thiadiazole possessing important biological activities.