Peptic ulcer is the areas of degeneration and necrosis of gastrointestinal mucosa exposed to acid peptic secretion. Some other factors, such as inadequate dietary habits, excessive ingestion of non-steroidal anti-inflammatory agents, stress, hereditary predisposition and infection by Helicobacter pylori, may be responsible for the development of peptic ulcer. The several herbal formulations derived from Ayurveda and its additional systems of medicine, not yet to be scientifically validated that they have exhibited anti-ulcer activity. Our present study was to evaluate the ulcer protective activity of ethanolic extract of Gynocardia odorata (G.   ordata) seeds on cold restraint and ethanol induced ulcer model. Five groups were taken (n=6). First groups serve as negative control (Without any treatment). Second groups were treated with vehicles only. Third groups were treated with some standard marketed drugs (Ranitidine and sucralfate). Fourth and fifth groups were treated with ethanolic seed extract of G. odorata in two increasing dose (250 and 500mg/kg body weight p.o respectively). Both the group showed significant ulcer protective activity in a dose dependent manner.