American Journal of PharmTech Research

AJPTR

2249-3387

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AJPTR41082

Synthesis, characterization and antimicrobial activity of novel 5-substituted aryl-2,7-diphenyl-1,3,4-thiadiazolo-[3,2-a]-1,3,5-triazine derivatives

Basedia

Deepak Kumar

Shrivastava

Birendra

Dubey

B. K.

Sharma

Pankaj

School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India. T.I.T. College of Pharmacy, Anand Nagar, BHEL, Bhopal, M.P., India.

02 01 2014

4 1

A new class of heterocyclic compounds 1,3,4-thiadiazolo[3,2-a]-s-triazine have been synthesized as schiff’s base of 1,3,4- thiadiazole mix with ammonium acetate and various aromatic aldehyde treated in MW irradiation at 480 W. Reaction is based on microwave mediate multi-component reaction (MCRs). The structures of these compounds have been elucidated by spectral (IR, NMR & Mass) analysis. The title compounds were then evaluated for their in-vitro microbial activity against 2 gram –Ve bacteria (E.coli, K. pneumoniae), 2 gram +Ve bacteria (S.aerues, B.subtilis) and 1 fungal specie (A.niger). The some newly synthesized compounds have shown promising antimicrobial activity.

1 3 5-Triazine 1 3 4-Thiadiazole Thiosemicarbazone Schiff’s base Antibacterial Antifungal Multi-component reaction (MCRs)