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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>American Journal of PharmTech Research</journal-title>
        <abbrev-journal-title abbrev-type="publisher">AJPTR</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2249-3387</issn>
      <publisher>
        <publisher-name>undefined</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">AJPTR42011</article-id>
      <title-group>
        <article-title>Simultaneous Estimation of Paracetamol and Dicyclomine Hydrochloride by Spectrophotometric Method</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Manish</surname>
            <given-names>Sinha</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>VermaVivek</surname>
            <given-names>VermaVivek</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="epub" iso-8601-date="2014-04-01">
        <month>04</month>
        <day>01</day>
        <year>2014</year>
      </pub-date>
      <volume>4</volume>
      <issue>2</issue>
      <abstract>
        <p>A simple accurate, precise and reproducible spectrophotometric method has been developed and validated for the simultaneous estimation of Paracetamol and Dicyclomine hydrochloride in combined tablet dosage form by Q-Absorbance ratio method. Q-Absorbance ratio method involves two wavelengths the iso-absorptive point and  λmax of paracetmol i.e. 231.5 nm and 257 nm respectively in 6 : 4 ratio methanol: 0.1 N NaOH mixture.  The linearity was detected in the range of 2-12 µg/ml (R2 = 0.9997) for Paracetamol and 10-35 µg/ml (R2 = 0.9989) for Dicyclomine Hydrochloride. The accuracy existed between 98-102% and the %RSD was less than 2%. The developed method was validated for linearity, accuracy and precision as per ICH guidelines.</p>
      </abstract>
      <kwd-group kwd-group-type="author">
        <kwd>Paracetamol</kwd>
        <kwd>Dicyclomine hydrochloride</kwd>
        <kwd>Q-Absorbance ratio method.</kwd>
      </kwd-group>
    </article-meta>
  </front>
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