In the present research work nifedipine transdermal patch were prepared and optimized by using D-optimal mixture design. The prepared transdermal patches were evaluated for various parameters like drug excipients compatibility study, physicochemical evaluation, mechanical properties, In vitro drug release and In vitro permeation study. The result of evaluation parameters demonstrated a successful development of transdermal patch with poly vinyl pyrrolidone (PVP) and ethyl cellulose (EC) as rate controlling polymer.