American Journal of PharmTech Research AJPTR 2249-3387 undefined AJPTR42029 Synthesis and Antihypertensive Screening of Novel Substituted 1,2- Pyrazoline Sulfonamide Derivatives Bhagwat Avinash M. Bhat Anilchandra R. Palled Mahesh S. Khadke Anand P. Patil Anuradha M. 04 01 2014 4 2

The novel compounds containing two phenyl rings at 3, 5 position of 1, 2-pyrazoline sulphonamide derivatives synthesized. N-((3-(4-aminophenyl)-5-(3,4-disubstitutedphenyl)-4,5-dihydropyrazol-1-yl)methyl)benzenamine screened  for Angiotensin II receptor antagonistic activity  in  1K-1C goldblatt hypertensive rats using tail cuff method. N-((3-(4-aminophenyl)-5-(3,4-dichlorophenyl)-4,5-dihydropyrazol-1-yl)methyl)benzenamine sulphonamide exhibited potent antihypertensive activity.

 1 2-pyrazoline sulfonamide angiotensin II antihypertensive