There is highly co-incidence between hypertension and insulin resistance which is the important causative factor to develop diabetes mellitus (DM). Our study was prospective study in effect of beta-blockers, angiotensin-converting enzyme inhibitor (ACEI) and calcium channel blocker (CCB) on blood glucose level in patients newly diagnosed with hypertension and without diabetes in MVJ hospital, Bangalore. Fasting blood glucose and post prandial blood glucose measured for patients prescribed antihypertensive for four months. In a nutshell, we observed that Beta blockers worsen the glycemic condition and it increased blood glucose level, beside that it increased incident of impaired glucose tolerance. In case of calcium channel blocker and ACEIs, blood glucose level slightly increased and decreased respectively after two months.