Pain in orofacial region is frequently observed in dentistry due to dryness of mouth (Xerostomia).  The commonly used drugs like antihistamines, antihypertensives etc and disease like diabetes may induce dryness of mouth. Treatment with conventional drugs has side effects. Hence, natural remedy with herbal drugs mainly Zingiber officinale a well known hepatoprotective, antiemetic and antiarthritic drug as a possible alternative in treatment of Xerostomia has been viewed in this paper. Key words:  Dryness of mouth, Zingiber officinale, salivary secretion