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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>American Journal of PharmTech Research</journal-title>
        <abbrev-journal-title abbrev-type="publisher">AJPTR</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2249-3387</issn>
      <publisher>
        <publisher-name>undefined</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">AJPTR43024</article-id>
      <title-group>
        <article-title>A Newer validated and stability indicating UPLC Method for the Estimation of Nordette in Tablet Formulation</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Sreeram</surname>
            <given-names>V.</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Prof.M.V.BasaveswaraRao</surname>
            <given-names>Prof.M.V.BasaveswaraRao</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>A.V.D.Nagendrakumar</surname>
            <given-names>A.V.D.Nagendrakumar</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>V.N.V.Kishore</surname>
            <given-names>V.N.V.Kishore</given-names>
          </name>
          <xref ref-type="aff" rid="aff3"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">Department of Chemistry, Dr.M.R.A.R. Campus, Krishna University, Krishna district, A.P.,INDIA.</aff>
      <aff id="aff2">Department of Chemistry, GITAM University, Visakhapatnam-530 045, Andhra Pradesh, India</aff>
      <aff id="aff3">Department of chemistry, A.G.&amp; S.G.Siddhartha College of Arts &amp; Science, Vuyyuru, Krishna (Dt) - 521165.A.P.INDIA</aff>
      <pub-date pub-type="epub" iso-8601-date="2014-06-01">
        <month>06</month>
        <day>01</day>
        <year>2014</year>
      </pub-date>
      <volume>4</volume>
      <issue>3</issue>
      <abstract>
        <p>A simple, selective, linear, precise and accurate UPLC Method was developed and validated for rapid assay of Nordette in tablet Formulation. Isocratic elution at a flow rate of 0.4ml/min was employed on C8 1.7 µm (2.1 mm x 100 mm) Column at ambient temperature40 °C. Injection Volume was found to be 5.0 µl. The mobile phase consisted of Acetonitrile : Water  60:40 v/v which is filter through a 0.2 µm filter The UV detection wavelength was 220nm and 2µl sample was injected. The retention time for Ethinylestradiol, Levonorgestrel is found to be ± 1.4 minutes and ± 2.1 minutes respectively. A linear regression curve was constructed, and the correlation coefficients (R2) and assessment values calculated. The percentage RSD for both Ethinylestradiol, Levonorgestrel was found to be 1.5%.The Accuracy of method ranges between 97.0 – 102.8%.  The method was validated as per the ICH guidelines. The method was successfully applied for routine quality control analysis of pharmaceutical formulation.</p>
      </abstract>
      <kwd-group kwd-group-type="author">
        <kwd>Nordette</kwd>
        <kwd>Ethinylestradiol</kwd>
        <kwd>Levonorgestrel</kwd>
        <kwd>UPLC</kwd>
        <kwd>Recovery</kwd>
        <kwd>Precise.</kwd>
      </kwd-group>
    </article-meta>
  </front>
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