A simple, precise and sensitive reverse-phase high performance liquid chromatographic method was developed and validated for the simultaneous estimation of Ramipril and Metoprolol tartarate in pharmaceutical formulations. Chromatographic separation was performed on a High performance liquid chromatography equipped with auto sampler and UV detector. Good sensitivity for all analyte was observed with UV detection at wavelength of 218 nm, Separation was performed on a BDS Hypersil C18 (250 X 4.6mm) 5µm, using a mixture of 0.1% Triethylamine buffer pH 3.5 and Acetonitrile in the ratio of (10:90, v/v). The method results in excellent separation with good resolution between the two analytes. The within day variation %RSD values between Ramipril and Metoprolol tartarate were 0.55 and 0.82. The recovery was greater than 98% with %RSD less than 1.00. The method was validated according to ICH guidelines by performing linearity, accuracy, precision, limits of quantitation and selectivity. The results show the method is suitable for its intended use.