The objective of this present study is to formulate and evaluate the floating drug delivery system of Bambuterol HCl prepared by using synthetic polymers. Formulations were prepared by direct compression technique and sodium bicarbonate was incorporated as gas generating agent. Using different polymers of hydroxyl propyl methylcellulose (HPMC) such as, HPMC K100M, HPMC K4M and HPMC K100M for their gel-forming properties. The compressed Bambuterol HCl floating tablets were evaluated for physical parameters like Tablet Thickness, Hardness, % Friability, Weight variation, Content uniformity, In vitro buoyancy, Swelling index and In vitro dissolution study. Its bioavailability was reported about 20%. As the concentration of the polymers in the formulations increased the drug release decreased. Hence it was considered suitable candidate for formulation as gastro-retentive floating drug delivery system. Floating tablets has been accepted as a process to achieve controlled drug delivery by prolonging the residence time of the dosage form at the site of absorption, thereby improving and enhancing the bioavailability of drug.