The objective of this research work was to formulate and evaluate the floating drug delivery system containing Pantoprazole sodium sesquihydrate as a model drug and to optimize its drug release profile. Pantoprazole sodium tablets were prepared by direct compression technique. Formulations contained Xanthan gum, PVP K30 and gas generating agent such as sodium bicarbonate and citric acid were taken as independent variables. The physical parameters of the tablets were characterized and were found within the limits. By comparing dissolution profiles of different formulations, the formulation F5 was considered as a better formulation. The drug release from all the formulations was found to follow zero order kinetics and Peppas modeling. The diffusion exponent of formulations was found (n