Herbal medicines are formulations of therapeutic herbs to prevent and treat disease and ailments or to promote health and healing. There are various aspects Indian manufactures have to focus on to establish their products in the global markets. Right from the analysis of raw materials and in-process testing to analysis of finished products, system have to be established to stringently monitor every step in the manufacture. Maintaining quality of herbal products includes a strict set of processes within the specified limits laid down by the World Health Organization (W.H.O) to maintain consistency. D-Diabetes S.M.A.R.T powder is an authentic ayurvedic preparation consisting of nineteen herbal medicines namely Acacia arabica, Asphaltum, Bombax ceiba, Butea monosperma, Emblica officinalis, Eugenia jambolana,Ficus bengalensis, Gymnema sylvestre,Holarrhena antidysentrica, Momordica charantia,Pistacia integerrima, Plumbago zeylanica, Pongamia glabra, Pterocarpus marsupium, Santalum album, Swertia chirata, Terminalia chebula, Tribulus terrestris and Woodfordia fruticosa. The herbal medicines Eugenia jambolana,Gymnema sylvestre, Momordica charantia and Tribulus terrestrisare present in maximum quantity in the formulation and can be chosen as biological standard for studies. World Health Organization has set specific guidelines for assessment of safety, efficacy and quality herbal medicines. The various steps involve are botanical parameter, physicochemical parameters, biological parameters, toxicological parameters and pharmacological parameters.