The present work deals with the synthesis of azetidinone derivatives of quinazolinones and  the structures of the compounds obtained have been established based on spectral (IR, 1H NMR,13C NMR and Mass) data. The present study also involves in vitro anthelmintic and antibacterial activity of the synthesized derivatives a few strains (gram positive and gram negative) of bacteria. All the compounds showed against moderate to satisfactory activities.