Wound is a physical injury that causes breakdown in the protective function of the skin and the loss of continuity of epithelium with or without loss of underlying connective tissues. Proper healing of wound is essential for the restoration of normalcy in disrupted anatomical continuity and altered functional status of the skin. Wound healing is a complex and dynamic process of restoring cellular structures and tissue layers. It can be divided into 3 distinct phases: an immediate haemostatic phase, an early phase of re-epithelialization, a later phase of dermal repair and remodelling. The present investigation was undertaken to determine the efficacy of Butea monosperma leaves aqueous extract, isolated acidic ingredient and its newly synthesized amide analogue along with silver sulphadiazine as control on burn wound in Wistar albino rats. The histopathological examinations confirmed that the treated animals showed improved rate of epithelialization and wound contraction. On comparison among the impact of test compounds; it was further revealed that, the Butea monosperma leaves aqueous extract and synthesized amide analogue showed significant wound healing activity than isolated acidic ingredient.