The present study highlights the living condition and the ethnomedicinal knowledge of the Irulasin the Gingee hills, Villupuram District, Tamilnadu. Extensive field surveys were conducted in seven villages in Gingeetaluk. Living conditions and ethnobotanical knowledge were taken through personal interview. A total of 16 species of 11 families were documented. The present study observed that the Irulasin Gingee hills have very sound knowledge of medicinal values of plants. This type of studies may help in the pharmacological research in various dimensions.