Liver disease is a major health problem in all countries, especially in developing countries. The drugs available to treated liver disease may cause further damages. There is an urgent need of some herbal medicines to treat liver disease without causing any further damages. Psidium guajava is one of the important plant in the Myrtaceae family. P. guajava which was reported the antibacterial, antidiarrhoeal, antihyperglycemic, antimalarial, cytotoxic, antioxidant activity etc. The aim of this review to compile the data of the hepatoprotective activity of a P. guajava extract in a recent years.