An accurate, rapid, specific and stability indicating ultra performance liquid chromatographic method was developed and validated for the simultaneous estimation of Verapamil and Trandolapril in a combined pharmaceutical dosage form. The chromatographic separation was attained on Phenonemex Luna C18 (4.0 x 100 mm, 2.6mm) column by isocratic mode with the mobile phase components as 0.03M monobasic potassium phosphate buffer (pH6.5) and acetonitrile (70: 30v/v) at a flow rate of 1.0 mL/min and quantified at 210 nm. The average retention times for Trandolapril and Verapamil were 0.60 and 1.14 min, respectively. The UPLC method proposesoutstanding separation of two drugs with a good resolution of greater than 2.0 and tailing factor less than 2.0 with a run time of 3 minutes. The method shows linearity over the concentration range of 9-45 µg/mL for Verapamil and 0.1-0.5 µg/mL for Trandolapril with a correlation ≥ 0.999. The method is accurate with recoveries in the range of 98.0 -101.0% and precise with %RSD value lesser than2.0% for both the drugs. This method is very fast, cost saving, accurate and specific for the assay of commercially available tablets.