ABSTARCT Present study was carried out to accessed the traditional medicinal bioresources used in the East Siang District of Arunachal Pradesh, India as Arunachal Pradesh is a remote Indian territory where traditional medicines has been the main source of primary health management from time immemorial. This paper reports 99 medicinal plants used among the aborigines in at least 40 types of health problems among the tribal people inhibits the East Siang district of Arunachal Pradesh, India belong to 55 families. With 8 species, Solanaceae was recorded as the highest representing family then followed by Asteraceae and Rubiaceae with 5 species each. Almost all parts of the plants were recorded to use in the folk medical system. Keywords: Aborigines, Folk Medicine, Traditional knowledge, biologically active compounds.