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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>American Journal of PharmTech Research</journal-title>
        <abbrev-journal-title abbrev-type="publisher">AJPTR</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2249-3387</issn>
      <publisher>
        <publisher-name>undefined</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">AJPTR51048</article-id>
      <title-group>
        <article-title>Development of Stability Indicating UV Spectroscopy Method for the Estimation of Deferiprone in Pharmaceutical Formulation</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Barot</surname>
            <given-names>Hinesha</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Shah</surname>
            <given-names>Darshil</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>DilipMaheshwari</surname>
            <given-names>Dr.</given-names>
          </name>
          <xref ref-type="aff" rid="aff3"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">Dept. of Quality Assurance, L. J.Institute of Pharmacy, Ahmedabad.</aff>
      <aff id="aff2">Assistant professor, Dept. of Quality Assurance, L. J. Institute of Pharmacy, Ahmedabad.</aff>
      <aff id="aff3">Head of the Department, Dept. of Quality Assurance, L. J. Institute of Pharmacy, Ahmedabad.</aff>
      <pub-date pub-type="epub" iso-8601-date="2015-02-01">
        <month>02</month>
        <day>01</day>
        <year>2015</year>
      </pub-date>
      <volume>5</volume>
      <issue>1</issue>
      <abstract>
        <p>The study describes the simple, sensitive, accurate, rapid and reliable ultra violet spectroscopic method has been developed for determination of Deferiprone in bulk drug and pharmaceutical formulation. Deferiprone is use as second line agent for thalassemia when iron overload from blood transfusion occurs.in order to investigate the stability of drug, a stress testing of drug sample by exposing it to variety of force degradation conditions has been recommended. Deferiprone was subjected to stress degradation under different condition recommended by international conference on harmonization (ICH). Deferiprone shows maximum absorbance at 279nm &amp; calibration graph linear in the concentration range 5-25 Mcg/ml with correlation co-efficient 0.9997.The higher percentage of recovery study indicates that there is no interference of excipients in the presence of formulation. The stability study indicates appreciable changes were observed by treating the drug with acidic hydrolysis, basic hydrolysis and oxidation. However, there is no appreciable changes were observed for thermal stress and photolytic degradation.</p>
      </abstract>
      <kwd-group kwd-group-type="author">
        <kwd>Deferiprone</kwd>
        <kwd>UV spectroscopy</kwd>
        <kwd>Force degradation</kwd>
        <kwd>Stability indicating method</kwd>
        <kwd>Validation.</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
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