The current review provides an in-depth discussion of multiple factors influencing microspheres formation which ranging from degree of speed by homogenizers, duration of mixing, concentration of polymers, selection of aqueous and oily phase and their ratios, viscosity role, and reasons behind different sizes of spheres, texture of microspheres ie. rough or smooth, entrapment efficiency, role of emulsifier, importance of cross linking agents with their concentration, solubility ,temperature influence in formation of spheres, solvent selection criteria, drug delivery from surface of microspheres etc. forms ground work and essential to go through all above mentioned factors in order to develop of ideal and in turn to improve stability of microspheres as multi particulates and improve knowledge behind updates of production of microspheres.