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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>American Journal of PharmTech Research</journal-title>
        <abbrev-journal-title abbrev-type="publisher">AJPTR</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2249-3387</issn>
      <publisher>
        <publisher-name>undefined</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">AJPTR53034</article-id>
      <title-group>
        <article-title>Synthesis and Pharmacological Evaluation of Novel 1-(2, 6-Difluorobenzyl)-1h-1, 2, 3-Triazole Derivatives for Cns Depressant and Anticonvulsant Profile</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Shukla</surname>
            <given-names>Jagdish D.</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Khan</surname>
            <given-names>Pathan Md. Arif Ali</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Deo</surname>
            <given-names>Keshav</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">Department of Chemistry, Maulana Azad college, Dr. Rafiq Zakaria Campus, Rauza Baugh, Aurangabad (M.S.), INDIA.</aff>
      <aff id="aff2">Wockhardt Research center, D- 4, MIDC, Chikalthana, Aurangabad (M.S.), INDIA.</aff>
      <pub-date pub-type="epub" iso-8601-date="2015-06-01">
        <month>06</month>
        <day>01</day>
        <year>2015</year>
      </pub-date>
      <volume>5</volume>
      <issue>3</issue>
      <abstract>
        <p>A series of 1-(2, 6-difluorobenzyl)-1H-1, 2, 3-triazole (5a-d and 7a-d) were synthesized and evaluated for CNS depressant  and anticonvulsant activities by photoactometer, rotarod and pentylene tetrazole induced convulsion method respectively in Swiss albino mice. Diazepam was used as a standard drug. Out of the 8 compounds tested, compounds (5b, 7a and 7b) were showed the CNS depressant activity comparable to that of diazepam at a dose of 5 mg/kg. The active members of the series (5b, 7a and 7b) were selected for anticonvulsant activity study.</p>
      </abstract>
      <kwd-group kwd-group-type="author">
        <kwd>1</kwd>
        <kwd>2</kwd>
        <kwd>3-triazole</kwd>
        <kwd>CNS depressant</kwd>
        <kwd>Pentylenetetrazole</kwd>
        <kwd>Clonic convulsions.</kwd>
      </kwd-group>
    </article-meta>
  </front>
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