American Journal of PharmTech Research AJPTR 2249-3387 undefined AJPTR54009 Formulation and Evaluation of Floating Matrix Tablets of Dipyridamole Kumar Kiran Srikanth P. Ajitha M. Y Madhusudan Rao Department of Pharmaceutics Vaagdevi Institute of Pharmaceutical Sciences. Bollikunta, Warangal – 506005, Telangana State. India R&D Cell JNTUH kukatpally Hyderabad-500085. 08 01 2015 5 4

Single unit floating effervescent matrix tablets of Dipyridamole were successfully prepared with hydrophilic polymers like HPMC K4M , HPMC K15M and HPMC K100M with 10% NaHCO3 by Simple direct compression method with drug: polymer ratio of 1:1.5,1:2,1:2.5:1.3. FT-IR studies were conducted between drug, polymer and various excipients used in the formulations. Evaluation parameters of powder blend like Hausner’s ratio, Compressibility index, Angle of repose were carried out and results showed that the powder has good flow properties. Formulated tablets gave satisfactory results for various evaluation parameters like tablet hardness (5-6 Kg/cm2), weight variation (±10%), Friability (

 Dipyridamole Radiographic Studies Hydrophilic Polymers Floating Effervescent Matrix Tablets.