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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>American Journal of PharmTech Research</journal-title>
        <abbrev-journal-title abbrev-type="publisher">AJPTR</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2249-3387</issn>
      <publisher>
        <publisher-name>undefined</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">AJPTR54014</article-id>
      <title-group>
        <article-title>Anti-Ulcer Activities of Methanolic Extract of Artocarpusaltilis (Breadfruit) on Alcohol Induced Acute Ulcer Model in Albino Wistar Rats</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>AA</surname>
            <given-names>Ajah</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>OJ</surname>
            <given-names>Olorunfemi</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>CPR</surname>
            <given-names>Chike</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>ME</surname>
            <given-names>Balogun</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>O</surname>
            <given-names>Obia</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>O</surname>
            <given-names>Adienbo</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Choba, Port Harcourt, Nigeria.</aff>
      <aff id="aff2">Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Choba, Port Harcourt, Nigeria.</aff>
      <pub-date pub-type="epub" iso-8601-date="2015-08-01">
        <month>08</month>
        <day>01</day>
        <year>2015</year>
      </pub-date>
      <volume>5</volume>
      <issue>4</issue>
      <abstract>
        <p>The present work was designed to investigate the anti-ulcer activities of methanolic extract of artocarpusaltilis [breadfruit] on alcohol induce ulcer in male albino rats. Animals were administered orally with a single dose of 98‰ alcohol [depending on the animals’ weight] to induce ulcer. This resulted in significant increase in ulcer occurrence [exacerbation]. Both the induced and normal rats were divided into six groups of 5 rats each. Group 1 was the control group [induced but not treated] while group 2 received 100mg/kg dose of aqueous extract of artocarpusaltilis. Group 3 and 4 received 200mg/kg and 300mg/kg dose of aqueous extract of artocarpusaltilis respectively. Group 5 received 10mg/kg per oral dose of omeprazole [standard drug]. Administration of methanolic extract of artocarpusaltilis produce a decrease in ulcer occurrence in induced rats. The decrease in ulcer occurrence was significant [p‹0.005] with all the groups treated with methanolic extract of artocarpusaltilis when compared to the control group. But group 3 and 4 exclusively showed same potency when compared to group 5 [standard drug]. The decrease in ulcer incidence when compared to the control group [ulcer induced but not treated] and for exhibiting same potency with the standard drug shows that the extract of artocarpusaltilis  is effective in controlling ulcer and can be used as a substitute for the standard drug in managing or treating/controlling ulcer. Conclusively, methanolic extract of artocarpusaltilis has tremendous beneficial anti-ulcer values in the treatment of ulcer following oral administration.</p>
      </abstract>
      <kwd-group kwd-group-type="author">
        <kwd>Artocarpusaltilis</kwd>
        <kwd>Omeprazole</kwd>
        <kwd>anti-ulcer activities</kwd>
        <kwd>gastric ulcer</kwd>
        <kwd>ulcer index.</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
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</article>
