ABSTARCT Solanum spirale is a tribal medicinal food plant which is used among the Adi tribes of Arunachal Pradesh, India. The methanol extract of shoot and berry were studied for their total phenolic (Folin-Ciocalteu’s method) and total flavonoid contents (colorimetric method) to study antioxidant potential ((DPPH & ABTS). The extracts were recorded to contain considerable amounts of phenolic content (18.64±2.12 mg GAE/g) in shoot and 11.72±1.42 mg GAE/g) in mature berry and flavonoid content of (5.29±1.01 µM RE/g) in shoot&50.52±1.03 µM RE/g) in mature berry and antioxidant potentials were calculated as 29.85±1.25 µM/g in the ABTS assay of shoot and38.27±1.33µM/g in the ABTS assay of berry while 45.4±0.37µM/g in the DPPH assay of shoot and 52±0.92 µM/g in the DPPH assay of mature berry respectively. This work also discourse traditional use of Solanum spirale among Adi tribes of Arunachal Pradesh. Keywords: Solanum spirale, total phenolic, flavonoid content, antioxidant potential, tribals, medicinal food, ethnobotany.