The provision of medication information is among the most fundamental responsibilities of pharmacist because, it makes the person current, competitive and knowledgeable. For this patient drug information system (DIS) is developed which include dialogue with patient. It provide a clear, consistent and mandatory approach to achieve a visible standardized level of dialogue with each patient. Whereas several challenges are associated in implementation of this system are differing region wise which may include cultural and economic, limited communication, infrastructure, open door access for free government health spending etc. In addition to the general challenges few are problem of an absence of routinely collected indicator data and a shortage of individual with the skill or qualifications necessary to oversee drug information system, source of reliable information on drug consumption. The present article document highlights regarding (DIS) and some of the key challenges in developing drug information system and highlights priority development issues to improve capacity for collecting better information on patterns and trends in drug consumption