The analgesic and anti-inflammatory properties of Hibiscus cannabinus, a popular herb used for the management of pain and inflammation causing disorders was investigated in rats and mice. Significant antinociceptive was observed at higher dose of extract in writhing, tail immersion and hot plate animal models and anti-inflammatory activity was observed in carrageenan, serotonin and histamine induced paw edema in rats. The extract exhibit significant decreased paw edema in anti-inflammatory models. These results therefore indicate that Hibiscus cannabinus seed contains biologically active principles, which have potentials for the treatment of inflammatory processes.