To assess the influence pharmacist provided patient education on Health Related Quality of life in patients with cerebro vascular disease. This was a prospective observational and interventional study conducted in neurology department at JSS hospital, Mysore. Morisky medication Adherence Scale (MAS), Validated Stroke Specific Quality of Life Questionnaire (SSQoL), was applied to assess the medication adherence behavior and HRQoL in the enrolled patients. At the end of the study period, 78 patients completed all the study follow-ups and 2 patients were considered as drop outs because of the missed follow-ups. The male population (75%) was three folds predominant than the female population (25%) in the study. Hypertension was observed as the major risk factor for stroke in the study patients. At the end of the study, a statistically significant improvement (P