Efforts have been spend for discovering drugs from medicinal plants. Hibiscus sabdariffa plant a well known plant with many traditional uses for treating different aliments have been selected for canvassing pharmacological activities expressed by the different polarity extracts. Results showed significant antidiabetic activity at different concentrations of glucose solution (5, 10 and 20 mM) (p value < 0.001). Significant moderate anti-inflammatory activity comprising in membrane stabilizing activity were expressed by ethanolic extract ranging (29.573±0.709 - 55.040 ±1.659 %) (p value < 0.001) while mild activity were expressed by petroleum ether extract ranging (10.273±0.413 - 22.347± 1.049 %). Approximately similar thrombolytic activity was exhibited by both extracts ranging (56.663±1.3139-21.533±0.656) consider as significant activity in comparison to the control negative (p value < 0.0001). Results conclude canvass the pharmacological activities expressed by different polarity extracts which were showed significant activity in some aspects which may open new venue for production of new drugs derived from nature with less side effects.