American Journal of PharmTech Research

AJPTR

2249-3387

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AJPTR56018

Anti-ulcer Activity of Hydro Alcoholic Extract of Acridocarpus excelsus a. Juss Leavesin Rat

Patricia

Randrianavony

Albertine

Raharivelonina Eddie

Nicolas

Randrianjafitrimo

Nat

Quansah

Fanantenanirainy

Randimbivololona

Laboratoire de Pharmacologie Générale, de Pharmacocinétique et de Cosmétologie, Faculté des Sciences, Université d’Antananarivo, MADAGASCAR. SIT (School for International Training) Study Abroad / World Learning Summer Program: Madagascar Traditional Medicine and Health Care Systems, Antananarivo, MADAGASCAR

12 01 2015

5 6

The anti ulcer activity of the hydro alcoholic extract of the leaves of Acridocarpus excelsus was studied in vivo using WISTAR rats. This study investigated the extract’s effect on gastric ulcer induced by indomethacin orally administered at the dose of 30mg/kg, acid secretion by pylorus ligation and mucus secretion. The results obtained showed that ulceration provoked by the indomethacin on the gastric mucosa surface was reduced from 13.12 ± 0.96 mm2 found inthe control group to 8.15± 0.12 mm2, 2.87 ± 0.41 mm2 and 1.25 ± 0.05 mm2 respectively in the rats treated with the extract at doses 150 mg/kg, 300 mg/kg and 600mg/kg (p

anti-ulcer Acridocarpus excelsus rats.