Dalbergia sissoo (family: Fabaceae) is an Asian deciduous rosewood tree. It is the state tree of Punjab state (India) called as Shisham used for antipyretic, emesis, ulcers, leucoderma, stomach troubles and skin disease, memory enhancer etc. The aim of this study is to evaluate the antidepressant activity of ethanolic leaf extracts of Dalbergia sissoo in mice. The animals were divided into five groups of 6 each. Group I was considered as normal control, II as Standard control (Imipramine), III, IV and V was treated group (ethanolic leaf extracts of Dalbergia sissoo 300, 450 and 600 mg/kg respectively). The animals were acclimatized for behavioral tests like Tail suspension test and Forced swim Test. In behavioral model of depression Tail suspension test and Forced swim Test, ethanolic leaf extracts of Dalbergia sissoo decreased the immobility time significantly and increase in the first latency in dose dependent manner. The findings in the behavioral model of depression showed significant effect was due to the monoamine theory of depression.