Indomethacin is a drug belongs to class NSAIDs used in the treatment of inflammatory rheumatoid diseases and relieve acute pain, period pain and pain after surgery and fever. This study aimed at evaluating some quality control parameters to compare the quality, safety, and efficacy of three brands of Indomethacin capsules available in the Indian market. In the present study three marketed formulations of Indomethacin of 25 mg strength were analyzed with quality parameters like Weight variation test, Disintegration test and In-vitro bioequivalence study with developed spectrophotometric analytical method. The Indomethacin capsule, Microcid exhibited highest in-vitro drug release 97.05% and lowest Disintegration time 320 sec. compared to other brands of Indomethacin capsule.