Polymer grafting open a new window to pharmaceutical formulation. This article review about the different natural polymer and their application in pharmaceutical industry. Techniques such as grafting, crosslinking, blending and composite formation techniques are accustomed to modify the polymer. Recently, polymer grafting method received a wide attention than the other methods employed in the modification of the polymer. Polymer grafting can be achieved by covalent bonding of monomer to the polymer. In this review, techniques such as chemical grafting, radiation grafting etc. are also discussed.