There are folkloric claims that Aloe vera has many pharmacological properties which have not been conclusively investigated. The aim of the study is to investigate the protective/toxic effects of chronic administration of Aloe vera gel extract on the haemostasis, haematology and renal handling of electrolytes, urea and creatinine in Wistar rats. The experimental animals were grouped into four: group 1(control) received vehicle and the test groups (2,3,4) received different doses of the extract (200, 300, and 500mg bwt/day ) respectively for 21 days. The bleeding time significantly decreased as the concentration of the extract increased while the clotting time increased relative to the control (P0.05). From the results of this study, it can be concluded that the chronic administration of Aloe vera gel did not disrupt the renal function of the wistar rats.