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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>American Journal of PharmTech Research</journal-title>
        <abbrev-journal-title abbrev-type="publisher">AJPTR</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2249-3387</issn>
      <publisher>
        <publisher-name>undefined</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">AJPTR63018</article-id>
      <title-group>
        <article-title>A  Novel UV-Spectrophotometric Method Development and Validation of Dolutegravir In Bulk and Its Laboratory Synthetic Mixture</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>SK.Masthanamma</surname>
            <given-names>SK.Masthanamma</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>K.Vasundhara</surname>
            <given-names>K.Vasundhara</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>S.Srilakshmi</surname>
            <given-names>S.Srilakshmi</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>SK.Fathimabi</surname>
            <given-names>SK.Fathimabi</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="epub" iso-8601-date="2016-06-01">
        <month>06</month>
        <day>01</day>
        <year>2016</year>
      </pub-date>
      <volume>6</volume>
      <issue>3</issue>
      <abstract>
        <p>Present  study  describes  the  spectrophotometric  method  development  and  subsequent  validation  of  dolutegravir  with  greater  precision  and  accuracy.  AIDS  is  the  most  dreadful  disease  in  the  society;  this  has  a  very  high  mortal  rate  among  the  countries,  as  results  loosing  many  beneficial  personalities.  There  are  many  antiviral  and  antiretroviral  drugs,  brought  forward  by  many  efficient  scientists. A  simple,  accurate,  novel,  safe,  and  precise  method  could  be  developed  for  the  estimation  of  Dolutegravir.  Spectrophotometric  measurements  were  carried  out  using  Schimadzu    double  beam(UV-1800  model)  Ultra  violet  visible  spectrophotometer  with  10mm  matched  quartz  cells  and  water  as  solvent. Linearity  for  the  method  was  found  in  the  range  of  2-14μg/ml  (r2=0.997).  Tablet  formulation  was  analyzed  and  %  assay  for  the  absorption  maxima  was  found  to  be  95.6%. The proposed method was validated as  per  ICH  guidelines.  Validated  studies  demonstrated  that  proposed  method  is  simple,  accurate,  precise,  specific,  rapid,  reliable,  and  reproducible.</p>
      </abstract>
      <kwd-group kwd-group-type="author">
        <kwd>Dolutegravir</kwd>
        <kwd>spectroscopy</kwd>
        <kwd>dosage form</kwd>
        <kwd>validation.</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
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