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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>American Journal of PharmTech Research</journal-title>
        <abbrev-journal-title abbrev-type="publisher">AJPTR</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2249-3387</issn>
      <publisher>
        <publisher-name>undefined</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">AJPTR65032</article-id>
      <title-group>
        <article-title>An Effective Novel Strategy of Combined Plants Extract for the Treatment of Parkinson&apos;s Disease</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Alam</surname>
            <given-names>Parwez</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Gupta</surname>
            <given-names>Jyoti</given-names>
          </name>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Firdouse</surname>
            <given-names>Seema</given-names>
          </name>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
      </contrib-group>
      <aff id="aff1">Singhania University, Pacheri Bari, Jhunjhunu- 333515, Rajasthan, India.</aff>
      <aff id="aff2">MVN University, Palwal-121105, Haryana, India.</aff>
      <pub-date pub-type="epub" iso-8601-date="2016-10-01">
        <month>10</month>
        <day>01</day>
        <year>2016</year>
      </pub-date>
      <volume>6</volume>
      <issue>5</issue>
      <abstract>
        <p>The aim of present study was an effective novel strategy of combined plants extract for the treatment of Parkinson’s disease, using Amla Withania and Tulsi extract in different ratio. The extracts were prepared by using solvents like 60% ethanol for Amla fruit, 50% ethanol for Withania root and pure ethanol for Tulsi aerial part. Haloperidol was used to induce catalepsy and Akinesia. The ability of these combined extracts in inhibition of haloperidol-induced catalepsy and Akinesia in rodent models of Parkinsonian symptoms also Motor co-ordination test was conducted using a rota rod apparatus. It was found that treatment with the extract signiﬁcantly reduced catalepsy according to dose.  In the second experiment haloperidol was used to suppress locomotor activity in test. Treatment with extract signiﬁcantly increased locomotion reduced by haloperidol according to dose.</p>
      </abstract>
      <kwd-group kwd-group-type="author">
        <kwd>Amla fruits</kwd>
        <kwd>Withania roots</kwd>
        <kwd>Tulsi aerial parts</kwd>
        <kwd>Extracts</kwd>
        <kwd>Parkinson’s disease.</kwd>
      </kwd-group>
    </article-meta>
  </front>
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