In order to explore pharmaceutical activity of marine fungi fungal samples were collected from both marine water and marine mud  of coastal lines in Andhra Pradesh, India. . Fungal samples were screened and identified as C.geniculatus. Screened marine fungi were evaluated for therapeutic activities which include antimicrobial, Anti-oxidant, Antidiabetic and anti-inflammatory activities. Pure cultures of these strain were fermented for 10 to 15 days, which resulted in the production of crude extract. The crude extract was separated, condensed,, weighed and stored for further analysis. Crude extract was analyzed for antibacterial and antifungal activities using agar well diffusion method at four different concentrations. Anti-oxidant by DPPH method, Antidiabetic by alpha amylase activity and anti-inflammatory activities by 5-LOX methods were done.  Antimicrobial activity was done with nine bacterial strains and five fungal strains. C.geniculatus showed good inhibitory activity against bacterial Streptococcus mutans, Lactobacillus casei and Enterococcus faecalis strains and  fungal strain Fusarium oxysporium. At maximum concentration DPPH method showed 92.58% radical scavenging activity, amylase activity showed 79.26% activity and 5 LOX method showed moderate activity at 51.72% of anti-inflammatory activity at this concentration.