Hypothyroidism is emerging as one of the global health issues. The analysis of the symptomatology of Hypothyroidism in the light of Ayurvedic principles reveals that the pathogenesis and manifestations of hypothyroidism occurs due to dysfunction of Agni. The trial drug Triphladya Guggulu, cited in Yogaratnakara for the management of Gandamala, contains Deepana, Pachana, Anulomana and Vatakapha shamaka drugs, targeting the Agni which is the main seat of pathogenesis. Pharmacognostical & Analytical study of Triphaldya Guggulu has been carried out for the evaluation of its efficacy in Hypothyrodism. On pharmacognostical study, Starch grains & fibres of Shunthi, Black debris of Maricha, Epidermal cells with Oil Globules & stone cells of Pippali, Sclerides of Haritaki & Vibhitaki, Trichoma of Vibhitaki, Tannin content of Haritaki, Fibres & silica deposition of Amalaki, Prismatic crystals & stone cells of Kanchnara were identified. Analytical study showed 10 spots at 254 nm and 11 spots at 366 nm.