To describe the various adverse donor reactions and determine the frequency of their occurrence in whole blood donors.  A retrospective review of all the no of donor Reactions reports of 19 blood banks of Kerala from 01/01/2014 to 31/12/2015 was done. The total number of donations were 246092(94.34%) and the Donors rejected were 14752(5.66%) 1174(0.48%) had an adverse reaction of which 999(0.41%) were vasovagal related and 175(0.07%) were needle injuries. Donor safety is an essential prerequisite to increase voluntary blood donation. AE analysis helps in identifying the blood donors at risk of AE, applying appropriate motivational strategies, pre-donation counseling, care during and after donation, developing guidelines and hemovigilance programme in countries with limited resources. Strict adherence to the rules is essential to ensure donor safety.  Also  it would have detrimental effects on return of donors for subsequent donations and rate of complications resulting in long-term morbidity and disablement is not negligible.