The aim of the present study was to evaluate the effect of Chromolaena odorata (C.odorata) and Boerhavia erecta (B.erecta) on lipid peroxidation and antioxidants in Lead acetate-induced Nephrotoxicity in male Wistar rats. The rats of the nephrotoxicity control group 2 were administered lead-acetate 10mg/kg body weight, intraperitoneally in 3 days once for 15 days. In nephrotoxicity rats, Oral treatment with C.odorata, B.erecta at a daily dose of (500 mg/kg b.wt) and silymarin (25 mg/kg b.wt) groups (3, 4 and 5) for last 15 days. The Lead-acetate-induced rats showed increase in the level of lipid peroxidation and decreased levels of superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione in serum and kidney. Oral treatment with C.odorata, B.erecta and silymarin in nephrotoxicity induced rats showed significantly decrease in the levels of kidney and serum lipid peroxidation and significant (p