Liquisolid technique is a new approach for delivery of drugs through oral cavity. This technique is suitable for poorly or water insoluble drugs and also for immediate or sustained release formulations. The technique is based upon the admixture of drug loaded solutions or liquid drug with appropriate carrier and coating materials to convert into acceptably flowing and compressible powder. The selection of non-toxic hydrophilic solvent, carrier, coating excipients and its ratios are independent of the individual chemical entities. Indirectly its leads to enhancement of bioavailibity. Liquisolid tablet of drug Tacrolimus were prepared by using PG, PEG 200, PEG 400, glycerin, Tween 80 and Span 80, as non volatile liquid vehicle, respectively. Tacrolimus is an immunosuppressive drug, which have poor water solubility and low bioavailability, so it is suitable for liquisolid technique. Also Tacrolimus is having daily dose 5-10 mg once a daily. FTIR and DSC studies reveal that there was no possible interaction between drug and tablet excipients. All the formulation was evaluated for disintegration time, hardness and friability time, in-vitro dissolution study.